Synthetic route identification: Identifying a synthetic route to manufacture niche Building Blocks, Scaffolds, Intermediate compounds for generating analogues

Custom Synthesis of Preclinical and Clinical compounds on a multi-gram to multi-kilo scale

Reference compounds or Standard Compounds useful in in-vitro assays and in-vivo animal model studies

Focused libraries to enable "Lead Generation" and "Lead Optimization" studies.

Generation of large libraries of 1000-1500 compounds per scaffold

Intellectual property (IP) generated in any FTE and FFS program belongs to the customer/sponsor

Projects that require flexibility and where there is little or no literature precedent for the proposed chemistry are done under a FTE model. Projects that have in-house protocols or clear literature procedures in the public domain are normally carried our under a Fee for Service model.

Process optimization: Identifying and commercializing alternate routes to manufacture niche intermediates / APIs that involve multi-step manufacturing processes. The objectives of process optimization services could be to significantly reduce the cost of manufacturing / complexity in manufacturing process, reduction in toxic by-products etc.

Contract Manufacturing : Company also undertakes commercial scale manufacturing of specific intermediates / APIs on behalf of originator companies. Company’s new infrastructure plans include setting up of USFDA approved manufacturing facilities.

Specialized Manufacturing: The company is well equipped to handle various specialized manufacturing processes that are hazardous in nature including Lithiations, Hydrogenations, Halogenations, Nitrations, Cyanations etc. These services are offered as part of the contract manufacturing services.

Avra has developed a commercially viable synthetic route for the key intermediates for Camptothecin derivatives which provides for significantly higher levels of drug purity.
Patent # = WO2007/-015259 A2

Avra Synthesis is part of Avra Laboratories and was started in 2007 to focus on the much neglected, specialty fine chemicals space in India

With increasing number of international pharmaceutical majors outsourcing their Contract Research and Custom Synthesis work to various companies in India, Avra Synthesis aims to provide high quality, pre-tested laboratory chemicals and reagents to various research organizations, companies and academic institutions

Avra Synthesis will be the only Indian CRO that offers specialty chemicals including customized chemicals for use by other laboratories

Objectives of Avra Synthesis:

To address needs of scientists working in research laboratories in India and abroad

Adhering to international standards of quality and complying with customer needs

To ensure off-the-shelf availability of most of the chemicals

Gram to kilogram quantities at the same purity for use in research & scale-up work

Customized products to meet requirements of those engaged in research 

Quality assurance to ISO standards